Real time detection of acute (IP) cocaine-enhanced dopamine and serotonin release in ventrolateral nucleus accumbens of the behaving Norway rat
Identifieur interne : 001322 ( Main/Exploration ); précédent : 001321; suivant : 001323Real time detection of acute (IP) cocaine-enhanced dopamine and serotonin release in ventrolateral nucleus accumbens of the behaving Norway rat
Auteurs : Patricia A. Broderick [États-Unis] ; Eugene P. Kornak Jr. [États-Unis] ; Frankie Eng [États-Unis] ; Robert Wechsler [États-Unis]Source :
- Pharmacology, Biochemistry and Behavior [ 0091-3057 ] ; 1993.
English descriptors
- Teeft :
- Accumbens, Actual detection time, Acute effects, Ambulation, Ascorbic acid, Baseline, Baseline photobeam interruptions, Behav, Behavioral chamber, Biochem, Brain power, Brain reward, Brain tissue, Broderick, Central ambulations, City university, Cocaine, Cocaine administration, Cocaine effects, Cocaineinduced release, Concurrent effect, Confidence limits, Data point, Dopamine, Dopamine release, Electrochemical, Electrochemical detection, Electrophysiologieal effects, Fine movement, Fine movements, First hour, Fisher plsd scheffe, Habituated behavior, Infrared photobeams, Intravenous cocaine, Locomotor, Locomotor activity, Mesoaccumbens dopamine system, Microelectrodes, Modulatory model, Movement behavior, Nacc, Neurochemical effects, Neuron, Neuronal circuits, Norway rats, Nucleus accumbens, Nucleus accumbens neurons, Opponent process theory, Oxford university press, Pearson coefficient, Pearson product, Percent change, Pharmacol, Photobeam, Photobeam interruptions, Plexiglas chamber, Present data, Previous studies, Progressive ratio schedule, Prosthetic acrylic, Psychostimulant, Psychostimulant behavior, Psychostimulant behaviors, Real time detection, Receptor, Release mechanisms, Reward signal, Same group, Second hour, Second hours, Serotonin, Serotonin release, Significant differences, Stereotyped behavior, Synaptic, Synaptic concentrations, Tegmental, Time course, Time period, Variation statistics, Ventral, Ventral tegmental area, Ventrolateral nucleus accumbens, Vivo, Vivo electrochemical, Vivo electrochemical signal, Vivo electrochemistry, Vivo microdialysis, Vivo voltammetry, Vlnacc.
Abstract
Abstract: Cocaine (10 mg/kg), administered intraperitoneal (IP), was studied for its effects on dopamine (DA) and serotonin (5-HT) release in ventrolateral nucleus accumbens (vlNAcc) of conscious and behaving male, virus-free, Sprague-Dawley rats with in vivo electrochemistry (voltammetry). Miniature stearate probes detected DA and 5-HT release, on line and within a temporal resolution of seconds. Psychostimulant behaviors, in the form of four behavioral components (i.e., the classically DA-dependent behaviors of locomotor activity [ambulations], rearing, and stereotypy, and a 5-HT-ergic behavior, central ambulations) were studied concurrently with infrared photobeam detection. The results show that (IP) cocaine significantly increased vlNAcc DA release (p < 0.0001) and 5-HT release (p < 0.0012). Each of the four parameters of cocaine-induced psychostimulant behavior was concurrently and significantly increased as well (ambulations: p < 0.0001; rearing: p < 0.0008; stereotypy: p < 0.0004; central ambulations: p < 0.0082). Moreover, exactly coincident data points for DA and 5-HT release occurred 10 and 40 min after (IP) cocaine administration. Cocaine-induced DA and 5-HT release were highly and positively correlated during the first hour of study (p < 0.01). As expected, increased DA release in vlNAcc after cocaine administration was significantly and positively correlated with classically DA-dependent behaviors (first- and second-hour effects) (p < 0.01) and with the 5-HT-ergic behavior, central ambulations (p < 0.01). Also, cocaine-induced 5-HT release was significantly and positively correlated with 5-HT behavior (p < 0.01). However, not as expected, classically DA-dependent behaviors were more positively correlated with cocaine-induced 5-HT release in vlNAcc throughout the two-hour period of study. Thus, the present findings show that 5-HT is a comediator with DA in the cocaine response in vlNAcc. Importantly, 5-HT may signal the known DA response to cocaine.
Url:
DOI: 10.1016/0091-3057(93)90567-D
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000824
- to stream Istex, to step Curation: 000804
- to stream Istex, to step Checkpoint: 000487
- to stream Main, to step Merge: 001338
- to stream Main, to step Curation: 001322
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Real time detection of acute (IP) cocaine-enhanced dopamine and serotonin release in ventrolateral nucleus accumbens of the behaving Norway rat</title><author><name sortKey="Broderick, Patricia A" sort="Broderick, Patricia A" uniqKey="Broderick P" first="Patricia A." last="Broderick">Patricia A. Broderick</name></author><author><name sortKey="Kornak Jr, Eugene P" sort="Kornak Jr, Eugene P" uniqKey="Kornak Jr E" first="Eugene P." last="Kornak Jr.">Eugene P. Kornak Jr.</name></author><author><name sortKey="Eng, Frankie" sort="Eng, Frankie" uniqKey="Eng F" first="Frankie" last="Eng">Frankie Eng</name></author><author><name sortKey="Wechsler, Robert" sort="Wechsler, Robert" uniqKey="Wechsler R" first="Robert" last="Wechsler">Robert Wechsler</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D7DAC8F299204FEC75BF3EA597723700925881EF</idno><date when="1993" year="1993">1993</date><idno type="doi">10.1016/0091-3057(93)90567-D</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-2KTNSC7V-C/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000824</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000824</idno><idno type="wicri:Area/Istex/Curation">000804</idno><idno type="wicri:Area/Istex/Checkpoint">000487</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000487</idno><idno type="wicri:doubleKey">0091-3057:1993:Broderick P:real:time:detection</idno><idno type="wicri:Area/Main/Merge">001338</idno><idno type="wicri:Area/Main/Curation">001322</idno><idno type="wicri:Area/Main/Exploration">001322</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Real time detection of acute (IP) cocaine-enhanced dopamine and serotonin release in ventrolateral nucleus accumbens of the behaving Norway rat</title><author><name sortKey="Broderick, Patricia A" sort="Broderick, Patricia A" uniqKey="Broderick P" first="Patricia A." last="Broderick">Patricia A. Broderick</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, The City University of New York Medical School</wicri:regionArea><wicri:noRegion>The City University of New York Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Kornak Jr, Eugene P" sort="Kornak Jr, Eugene P" uniqKey="Kornak Jr E" first="Eugene P." last="Kornak Jr.">Eugene P. Kornak Jr.</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, The City University of New York Medical School</wicri:regionArea><wicri:noRegion>The City University of New York Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Eng, Frankie" sort="Eng, Frankie" uniqKey="Eng F" first="Frankie" last="Eng">Frankie Eng</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, The City University of New York Medical School</wicri:regionArea><wicri:noRegion>The City University of New York Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Wechsler, Robert" sort="Wechsler, Robert" uniqKey="Wechsler R" first="Robert" last="Wechsler">Robert Wechsler</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, The City University of New York Medical School, USADepartments of Biology and Psychology, CUNY Graduate School, New York, NY 10031</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="ISSN">0091-3057</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1993">1993</date><biblScope unit="volume">46</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="715">715</biblScope><biblScope unit="page" to="722">722</biblScope></imprint><idno type="ISSN">0091-3057</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-3057</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Accumbens</term><term>Actual detection time</term><term>Acute effects</term><term>Ambulation</term><term>Ascorbic acid</term><term>Baseline</term><term>Baseline photobeam interruptions</term><term>Behav</term><term>Behavioral chamber</term><term>Biochem</term><term>Brain power</term><term>Brain reward</term><term>Brain tissue</term><term>Broderick</term><term>Central ambulations</term><term>City university</term><term>Cocaine</term><term>Cocaine administration</term><term>Cocaine effects</term><term>Cocaineinduced release</term><term>Concurrent effect</term><term>Confidence limits</term><term>Data point</term><term>Dopamine</term><term>Dopamine release</term><term>Electrochemical</term><term>Electrochemical detection</term><term>Electrophysiologieal effects</term><term>Fine movement</term><term>Fine movements</term><term>First hour</term><term>Fisher plsd scheffe</term><term>Habituated behavior</term><term>Infrared photobeams</term><term>Intravenous cocaine</term><term>Locomotor</term><term>Locomotor activity</term><term>Mesoaccumbens dopamine system</term><term>Microelectrodes</term><term>Modulatory model</term><term>Movement behavior</term><term>Nacc</term><term>Neurochemical effects</term><term>Neuron</term><term>Neuronal circuits</term><term>Norway rats</term><term>Nucleus accumbens</term><term>Nucleus accumbens neurons</term><term>Opponent process theory</term><term>Oxford university press</term><term>Pearson coefficient</term><term>Pearson product</term><term>Percent change</term><term>Pharmacol</term><term>Photobeam</term><term>Photobeam interruptions</term><term>Plexiglas chamber</term><term>Present data</term><term>Previous studies</term><term>Progressive ratio schedule</term><term>Prosthetic acrylic</term><term>Psychostimulant</term><term>Psychostimulant behavior</term><term>Psychostimulant behaviors</term><term>Real time detection</term><term>Receptor</term><term>Release mechanisms</term><term>Reward signal</term><term>Same group</term><term>Second hour</term><term>Second hours</term><term>Serotonin</term><term>Serotonin release</term><term>Significant differences</term><term>Stereotyped behavior</term><term>Synaptic</term><term>Synaptic concentrations</term><term>Tegmental</term><term>Time course</term><term>Time period</term><term>Variation statistics</term><term>Ventral</term><term>Ventral tegmental area</term><term>Ventrolateral nucleus accumbens</term><term>Vivo</term><term>Vivo electrochemical</term><term>Vivo electrochemical signal</term><term>Vivo electrochemistry</term><term>Vivo microdialysis</term><term>Vivo voltammetry</term><term>Vlnacc</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Cocaine (10 mg/kg), administered intraperitoneal (IP), was studied for its effects on dopamine (DA) and serotonin (5-HT) release in ventrolateral nucleus accumbens (vlNAcc) of conscious and behaving male, virus-free, Sprague-Dawley rats with in vivo electrochemistry (voltammetry). Miniature stearate probes detected DA and 5-HT release, on line and within a temporal resolution of seconds. Psychostimulant behaviors, in the form of four behavioral components (i.e., the classically DA-dependent behaviors of locomotor activity [ambulations], rearing, and stereotypy, and a 5-HT-ergic behavior, central ambulations) were studied concurrently with infrared photobeam detection. The results show that (IP) cocaine significantly increased vlNAcc DA release (p < 0.0001) and 5-HT release (p < 0.0012). Each of the four parameters of cocaine-induced psychostimulant behavior was concurrently and significantly increased as well (ambulations: p < 0.0001; rearing: p < 0.0008; stereotypy: p < 0.0004; central ambulations: p < 0.0082). Moreover, exactly coincident data points for DA and 5-HT release occurred 10 and 40 min after (IP) cocaine administration. Cocaine-induced DA and 5-HT release were highly and positively correlated during the first hour of study (p < 0.01). As expected, increased DA release in vlNAcc after cocaine administration was significantly and positively correlated with classically DA-dependent behaviors (first- and second-hour effects) (p < 0.01) and with the 5-HT-ergic behavior, central ambulations (p < 0.01). Also, cocaine-induced 5-HT release was significantly and positively correlated with 5-HT behavior (p < 0.01). However, not as expected, classically DA-dependent behaviors were more positively correlated with cocaine-induced 5-HT release in vlNAcc throughout the two-hour period of study. Thus, the present findings show that 5-HT is a comediator with DA in the cocaine response in vlNAcc. Importantly, 5-HT may signal the known DA response to cocaine.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><noRegion><name sortKey="Broderick, Patricia A" sort="Broderick, Patricia A" uniqKey="Broderick P" first="Patricia A." last="Broderick">Patricia A. Broderick</name></noRegion><name sortKey="Eng, Frankie" sort="Eng, Frankie" uniqKey="Eng F" first="Frankie" last="Eng">Frankie Eng</name><name sortKey="Kornak Jr, Eugene P" sort="Kornak Jr, Eugene P" uniqKey="Kornak Jr E" first="Eugene P." last="Kornak Jr.">Eugene P. Kornak Jr.</name><name sortKey="Wechsler, Robert" sort="Wechsler, Robert" uniqKey="Wechsler R" first="Robert" last="Wechsler">Robert Wechsler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001322 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001322 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:D7DAC8F299204FEC75BF3EA597723700925881EF
|texte= Real time detection of acute (IP) cocaine-enhanced dopamine and serotonin release in ventrolateral nucleus accumbens of the behaving Norway rat
}}
| This area was generated with Dilib version V0.6.33. |  |